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No certain dose adjustment suggested when tofacitinib coadministered with strong CYP2C19 inhibitors; reduce tofacitinib dose if coadministered with both of those reasonable CYP3A4 and strong CYP2C19 inhibitors .No certain dose adjustment recommended when tofacitinib coadministered with powerful CYP2C19 inhibitors; reduce tofacitinib dose if coadmin